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WHAT IS ASTHMA?
Asthma is a respiratory disease, usually characterized by chronic airway inflammation. It is defined by respiratory symptoms, such as wheezing, shortness of breath, chest tightness, and cough. These symptoms may vary over time and can be reversible.
IS YOUR ASTHMA
UNDER CONTROL?
Have you thought about a life with less Asthma? It’s important to understand the current level of your or your child’s asthma control.
AIRWAY Inflammation Can Be An Underlying Cause Of Asthma
Having asthma means your airways may be inflamed. This inflammation may cause your airways to narrow, making it harder to breathe properly. With treatment, airway inflammation in the lungs may improve, allowing you to breathe better.
Get a better understanding of asthma
You may be familiar with moderate-to-severe asthma, but are you confused about what uncontrolled asthma is? Do you know what defines OCS-dependent asthma?
uncontrolled asthma
Asthma is defined as uncontrolled when
a patient experiences 3 to 4 of the following
symptoms in a 4-week span:
Interrupted
sleep
Daytime asthma
symptoms
more
than twice a week
Rescue inhaler
use more
than
twice a week
Missed or limited
activities due to
asthma
OCS‑DEPENDENT asthma
Oral corticosteroid (OCS)–dependent asthma
is asthma that is either uncontrolled or
difficult to treat that relies on
OCS in addition to other medications to:
Help treat or
maintain good
symptom control
Reduce the risk of
attacks
eosinophilic
asthma
Eosinophilic asthma is a subtype of asthma that is often severe. It is often seen in adults who develop asthma in adulthood.
These patients have an increased amount of eosinophils present in their blood, lung tissue, and mucus coughed up from the respiratory tract.
Patients with this subtype of asthma do not typically have underlying allergies such as pollen, dust mites, smoke, and pet dander that trigger asthma symptoms.
What Can Cause asthma Attacks?
Hear from asthma specialist Dr Neil Jain
In this video, Dr Neil Jain answers common questions from asthma patients such as, “What are some underlying causes of an asthma attack?” and “How do I know if my asthma is being controlled?”
DR. JAIN: Most research suggests that asthma attacks may be caused by excess inflammation in the airways, which can lead to swelling of the airway, mucus production, and something called bronchoconstriction, where the airways clamp down, making it difficult to breathe.
When you inhale something such as pet dander or other allergens, your immune system can react aggressively, and inflammation can increase.
This can worsen your asthma symptoms and cause an attack.
Controlling the underlying inflammation in the lungs, regardless of whether you have any symptoms, may help prevent asthma attacks.
DR. JAIN: If your asthma is well controlled, you should be able to do most of the things you want to do without being limited by your breathing, and you should not need to use a rescue medication more than once a week.
You should not need oral or injected steroids for asthma exacerbations or attacks more than once in a year, and you should not be waking up at night more than once a month due to asthma symptoms.
DR. JAIN: DUPIXENT may be an option to treat uncontrolled moderate-to-severe asthma, as long as there is evidence for inflammation called eosinophilic present or you have oral steroid dependent asthma. Your doctor may do some bloodwork to see if eosinophilic inflammation is present prior to starting DUPIXENT.
Before starting DUPIXENT, you should talk to your doctor about all the medical conditions you have and the medications you are taking.
You and your doctor should also discuss the potential benefits and risks of treatment, including the most common side effects such as injection site reactions, and some serious side effects including allergic reactions that can sometimes be severe, inflammation of your blood vessels, and joint aches and pain.
VO:
ASTHMA PATIENT PROFILES:
A CLOSER LOOK
If you have a specific type of moderate-to-severe asthma, you don't have to let it stop you from DUing more. Here are a few
examples of patients who may consider DUPIXENT for treatment of their asthma.
Jennifer, 49
UNCONTROLLED SEVERE ASTHMA
Accounting manager
Gardener, amateur chef
Jennifer loves nothing more than tending to her home garden and sharing her food with family. Unfortunately, her uncontrolled asthma has made it difficult to enjoy outdoor activities, with the risk of an attack always looming.
Jennifer is not an actual DUPIXENT patient.
Treatment Goals
Fewer asthma
attacks
leading to
ER visits
attacks
leading to
ER visits
Less reliance
on
steroids
on
steroids
Background and Symptoms
- Limits outdoor activities due to fear of an attack
- Shortness of breath
- Nighttime awakening due to asthma
Current Treatments
- 3 oral steroid courses last year
- Corticosteroid combination inhaler
- Frequent use of rescue inhaler
Primary Asthma Specialist
- Pulmonologist
Discover how DUPIXENT differs from
Jennifer’s current treatments.
How DUPIXENT is Taken
Jennifer’s current treatments.
Harris, 28
MODERATE ASTHMA
Fitness club manager
Runner, outdoor enthusiast
Harris loves to run, but uncontrolled asthma symptoms make it difficult to meet his fitness goals. His training runs are often cut short by coughing fits or chest tightness that makes it hard to keep up with his running buddies.
Harris is not an actual DUPIXENT patient.
Treatment Goals
Better breathing
Play sports with less
asthma attacks
asthma attacks
Background and Symptoms
- Diagnosed with asthma as a child
- Difficulty breathing during outdoor activities
- Uses a rescue inhaler 2x/week
Current Treatments
- 1 oral steroid course last year
- Corticosteroid combination inhaler
- Frequent use of rescue inhaler
Primary Asthma Specialist
- Allergist
Explore how patients like Harris
have seen results with DUPIXENT in
as little as 2 weeks.
RESULTS WITH DUPIXENT
have seen results with DUPIXENT in
as little as 2 weeks.
Avery, 31
DEPENDS ON ORAL
CORTICOSTEROIDS
College student
Business major, fashion vlogger
Avery hides her struggles on social media, but her Asthma interrupts her sleep on a nightly basis, making it hard to keep up with her busy schedule. Her grades have slipped, and she rarely has the energy to spend time with her friends. Avery also fears that her active lifestyle will lead to an exacerbation, resulting in another trip to the ER.
Avery is not an actual DUPIXENT patient.
Treatment Goals
Less reliance
on steroids
on steroids
Reduced
exacerbations
exacerbations
Background and Symptoms
- Diagnosed with asthma 10 years ago
- Exacerbation leading to the ER despite 2 oral
steroid courses - Interrupted sleep due to asthma
Current Treatments
- Corticosteroid inhaler
- Rescue inhaler
- Multiple rounds of steroids
Primary Asthma Specialist
- Co-managed between Allergist and
Primary Care Provider
Learn how DUPIXENT works differently to help prevent Avery’s asthma attacks.
HOW DUPIXENT WORKS
Cade, 8
MODERATE TO SEVERE
PEDIATRIC ASTHMA
Baseball player, video game lover
Like many kids, Cade never seems to slow down—except when his asthma flares up. His asthma attacks consistently interrupt his favorite activities, whether he’s on the baseball field or simply playing in the backyard. His parents fear he will have an asthma attack while playing sports and want to minimize missed school days.
Cade is not an actual DUPIXENT patient.
Treatment Goals
Fewer symptoms
during activities
during activities
Less exacerbations,
less
missed school
days
less
missed school
days
Background and Symptoms
- Diagnosed with asthma as a toddler
- Often wheezes while playing sports
- 2 asthma exacerbations in the last year
requiring hospitalization
Current Treatments
- Medium dose inhaled corticosteroid + LABA
- Nebulized rescue treatment
Primary Asthma Specialist
- Co-managed between
Pulmonologist and
Pediatrician
Find out how children like Cade
could benefit from DUPIXENT.
RESULTS IN CHILDREN
could benefit from DUPIXENT.
IN THE KNOW ABOUT ORAL STEROIDS?
While oral steroids can be helpful when prescribed to treat uncontrolled asthma, there can be potential short-term and long-term risks with repeated use. Learn how a real DUPIXENT patient used DUPIXENT to help decrease his reliance on steroids and improve control of his asthma symptoms.
FREQUENTLY ASKED QUESTIONS
DUPIXENT is a prescription medicine used as an add-on maintenance treatment for adults and children 6 years of age and older who have moderate-to-severe eosinophilic or oral steroid dependent asthma that is not controlled with their current asthma medicines. DUPIXENT is not used to treat sudden breathing problems. Speak to your healthcare provider or find a specialist to learn if DUPIXENT is right for you.