A HOPE FOR ASTHMA
Have you thought about a life with less Asthma? It’s important to understand the current level of your or your child’s asthma control.
Type 2 Inflammation Can Be An Underlying Cause Of Asthma
This underlying inflammation may be playing a role in your uncontrolled moderate-to-severe asthma.
With asthma caused by Type 2 inflammation, a patient's immune system may react excessively to environmental exposures. This can lead to increases in blood eosinophils and inflammation in the lungs that worsen asthma symptoms and trigger attacks.
ASTHMA PATIENTS
have Type 2 inflammation
A Closer Look at Asthma Patients
If you have a specific type of moderate-to-severe asthma, you don't have to let it stop you from DUing more. Here are a few
examples of patients who may consider DUPIXENT for treatment of their asthma.
UNCONTROLLED SEVERE ASTHMA
Gardener, amateur chef
Jennifer loves nothing more than tending to her home garden and sharing her food with family. Unfortunately, her uncontrolled asthma has made it difficult to enjoy outdoor activities, with the risk of an attack always looming.
Jennifer is not an actual DUPIXENT patient.
Treatment Goals
attacks
leading to
ER visits
on
steroids
Background and Symptoms
- Limits outdoor activities due to fear of an attack
- Shortness of breath
- Nighttime awakening due to asthma
Current Treatments
- 3 oral steroid courses last year
- Corticosteroid combination inhaler
- Frequent use of rescue inhaler
Primary Asthma Specialist
- Pulmonologist
Jennifer’s current treatments.
MODERATE ASTHMA
Runner, outdoor enthusiast
Harris loves to run, but uncontrolled asthma symptoms make it difficult to meet his fitness goals. His training runs are often cut short by coughing fits or chest tightness that makes it hard to keep up with his running buddies.
Harris is not an actual DUPIXENT patient.
Treatment Goals
asthma attacks
Background and Symptoms
- Diagnosed with asthma as a child
- Difficulty breathing during outdoor activities
- Uses a rescue inhaler 2x/week
Current Treatments
- 1 oral steroid course last year
- Corticosteroid combination inhaler
- Frequent use of rescue inhaler
Primary Asthma Specialist
- Allergist
have seen results with DUPIXENT in
as little as 2 weeks.
DEPENDS ON ORAL
CORTICOSTEROIDS
Business major, fashion vlogger
Avery hides her struggles on social media, but her Asthma interrupts her sleep on a nightly basis, making it hard to keep up with her busy schedule. Her grades have slipped, and she rarely has the energy to spend time with her friends. Avery also fears that her active lifestyle will lead to an exacerbation, resulting in another trip to the ER.
Avery is not an actual DUPIXENT patient.
Treatment Goals
on steroids
exacerbations
Background and Symptoms
- Diagnosed with asthma 10 years ago
- Exacerbation leading to the ER despite 2 oral steroid courses
- Interrupted sleep due to asthma
Current Treatments
- Corticosteroid inhaler
- Rescue inhaler
- Multiple rounds of steroids
Primary Asthma Specialist
- Co-managed between Allergist and
Primary Care Provider
MODERATE TO SEVERE
PEDIATRIC ASTHMA
Baseball player, video game lover
Like many kids, Cade never seems to slow down—except when his asthma flares up. His asthma attacks consistently interrupt his favorite activities, whether he’s on the baseball field or simply playing in the backyard. His parents fear he will have an asthma attack while playing sports and want to minimize missed school days.
Cade is not an actual DUPIXENT patient.
Treatment Goals
during activities
less
missed school
days
Background and Symptoms
- Diagnosed with asthma as a toddler
- Often wheezes while playing sports
- 2 asthma exacerbations in the last year requiring hospitalization
Current Treatments
- Medium dose inhaled corticosteroid + LABA
- Nebulized rescue treatment
Primary Asthma Specialist
- Co-managed between
Pulmonologist and
Pediatrician
could benefit from DUPIXENT.
Get a better understanding of asthma
You may be familiar with moderate-to-severe asthma, but are you confused about what Uncontrolled asthma is? Do you know what defines OCS dependent asthma?
Learn more about different types of asthma below.
Uncontrolled asthma
Asthma is defined as uncontrolled when
a patient experiences 3-4 of the following
symptoms in a 4-week span:
Interrupted
sleep
Daytime asthma
symptoms
more
than twice a week
Rescue inhaler
use more
than
twice a week
Missed or limited
activities due to
asthma
ocs dependent asthma
Oral corticosteroid (OCS) dependent asthma
is asthma that is either uncontrolled or
difficult-to-treat that relies on
OCS in addition to other medications to:
Help treat or
maintain good
symptom control
Reduce the risk of
attacks
eosinophilic
asthma
Eosinophilic asthma is a subtype of asthma that is often severe. It is often seen in adults who develop asthma in adulthood.
These patients have an increased amount of eosinophils present in their blood, lung tissue, and mucus coughed up from the respiratory tract.
Patients with this subtype of asthma do not typically have underlying allergies such as pollen, dust mites, smoke, and pet dander that trigger asthma symptoms.
What Can Cause asthma Attacks?
Hear from asthma specialist Dr Neil Jain
In this video, Dr Neil Jain answers common questions from asthma patients such as, “What are some underlying causes of an asthma attack?” and “How do I know if my asthma is being controlled?”
DR. JAIN: Most research suggests that asthma attacks may be caused by excess inflammation in the airways, which can lead to swelling of the airway, mucus production, and something called bronchoconstriction, where the airways clamp down, making it difficult to breathe.
When you inhale something such as pet dander or other allergens, your immune system can react aggressively, and inflammation can increase.
This can worsen your asthma symptoms and cause an attack.
Controlling the underlying inflammation in the lungs, regardless of whether you have any symptoms, may help prevent asthma attacks.
DR. JAIN: If your asthma is well controlled, you should be able to do most of the things you want to do without being limited by your breathing, and you should not need to use a rescue medication more than once a week.
You should not need oral or injected steroids for asthma exacerbations or attacks more than once in a year, and you should not be waking up at night more than once a month due to asthma symptoms.
DR. JAIN: DUPIXENT may be an option to treat uncontrolled moderate-to-severe asthma, as long as there is evidence for inflammation called eosinophilic present or you have oral steroid dependent asthma. Your doctor may do some bloodwork to see if eosinophilic inflammation is present prior to starting DUPIXENT.
Before starting DUPIXENT, you should talk to your doctor about all the medical conditions you have and the medications you are taking.
You and your doctor should also discuss the potential benefits and risks of treatment, including the most common side effects such as injection site reactions, and some serious side effects including allergic reactions that can sometimes be severe, inflammation of your blood vessels, and joint aches and pain.
VO:
Important Safety
Information and Indication
Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.
Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you:
- have a parasitic (helminth) infection
- are scheduled to receive any vaccinations. You should not receive a "live vaccine" right before and during treatment with DUPIXENT.
- are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
- A pregnancy registry for women who take DUPIXENT during pregnancy collects information about the health of you and your baby. To enroll or get more information call 1-877-311-8972 or go to https://mothertobaby.org/ongoing-study/dupixent/.
- are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines or use an asthma medicine. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine or other asthma medicine to come back.
DUPIXENT can cause serious side effects, including:
- Allergic reactions. DUPIXENT can cause allergic reactions that can sometimes be severe. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms: breathing problems or wheezing, swelling of the face, lips, mouth, tongue, or throat, fainting, dizziness, feeling lightheaded, fast pulse, fever, hives, joint pain, general ill feeling, itching, skin rash, swollen lymph nodes, nausea or vomiting, or cramps in your stomach-area.
- Inflammation of your blood vessels. Rarely, this can happen in people with asthma who receive DUPIXENT. This may happen in people who also take a steroid medicine by mouth that is being stopped or the dose is being lowered. It is not known whether this is caused by DUPIXENT. Tell your healthcare provider right away if you have: rash, chest pain, worsening shortness of breath, a feeling of pins and needles or numbness of your arms or legs, or persistent fever.
- Joint aches and pain. Some people who use DUPIXENT have had trouble walking or moving due to their joint symptoms, and in some cases needed to be hospitalized. Tell your healthcare provider about any new or worsening joint symptoms. Your healthcare provider may stop DUPIXENT if you develop joint symptoms.
The most common side effects in patients with asthma include injection site reactions, high count of a certain white blood cell (eosinophilia), pain in the throat (oropharyngeal pain), and parasitic (helminth) infections.
Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Use DUPIXENT exactly as prescribed by your healthcare provider. It’s an injection given under the skin (subcutaneous injection). Your healthcare provider will decide if you or your caregiver can inject DUPIXENT. Do not try to prepare and inject DUPIXENT until you or your caregiver have been trained by your healthcare provider. In children 12 years of age and older, it’s recommended DUPIXENT be administered by or under supervision of an adult. In children 6 to less than 12 years of age, DUPIXENT should be given by a caregiver.
Please see accompanying full Prescribing Information including Patient Information.
Indication
DUPIXENT is a prescription medicine used with other asthma medicines for the maintenance treatment of moderate-to-severe eosinophilic or oral steroid dependent asthma in adults and children 6 years of age and older whose asthma is not controlled with their current asthma medicines. DUPIXENT helps prevent severe asthma attacks (exacerbations) and can improve your breathing. DUPIXENT may also help reduce the amount of oral corticosteroids you need while preventing severe asthma attacks and improving your breathing. DUPIXENT is not used to treat sudden breathing problems. It is not known if DUPIXENT is safe and effective in children with asthma under 6 years of age.
HOW DUPIXENT WORKS
Read about the benefits and risks of DUPIXENT, how DUPIXENT
performed in clinical trials, and much more.
FREQUENTLY ASKED QUESTIONS
DUPIXENT is a prescription medicine used as an add-on maintenance treatment for adults and children 6 years of age and older who have moderate-to-severe eosinophilic or oral steroid dependent asthma that is not controlled with their current asthma medicines. DUPIXENT is not used to treat sudden breathing problems. Speak to your healthcare provider or find a specialist to learn if DUPIXENT is right for you.