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HOW DUPIXENT WORKS
How DUPIXENT Works In The Lungs
Did you know, underlying inflammation may be ongoing even when asthma symptoms are not present?
Underlying inflammation in asthma may cause airways to become constricted and narrow, making it harder to breathe properly.
DUPIXENT blocks a key source of airway inflammation in the lungs.
Illustrative image of DUPIXENT mechanism only and not reflective of treatment effect.
Ready To DU More With Less Asthma?
Improves lung function
for
long-lasting
breathing improvement
Blocks a key source of
inflammation in the lungs
Not an inhaler,
steroid, or
immunosuppressant
Transcript
A LOOK INSIDE: THE SCIENCE OF DUPIXENT
Please stay tuned for additional Important Safety Information.
Hi there! I'm Pixi, and I help people learn about DUPIXENT.
Today, I'd like to help you understand how DUPIXENT works in your body to improve lung function so you can breathe better in as little as two weeks.
Let's use an analogy. It might be helpful to think of your asthma symptoms like spam calls.
Both are unwanted, persistent, and can disrupt your daily life.
Meet Mike, just an average cell phone that's going to help us with this analogy.
He's trying to relax and recharge when...
Poor Mike!
Unwanted interruptions can make mornings tough, and Mike's constant spam calls make simple activities such as getting a good start to the day, walking in the park, and meeting up with friends harder... just like your asthma symptoms can make the everyday things you want to do feel like "uphill" tasks.
Frankly, it's exhausting!
Right now, Mike has no way of blocking these unwanted spam calls. He needs a spam filter!
Similarly, you may have no way of blocking the unwanted signals in your lungs that can cause asthma symptoms.
See, you may have Type 2 inflammation. 8 out of 10 people with asthma do!
It means there's a constant underlying inflammation in your lungs, caused by immune cells sending out too many inflammatory signals.
All this extra signaling causes the muscles in the lungs to contract and produce too much mucus, narrowing your airways and reducing air flow.
Unlike oral steroids, DUPIXENT targets an underlying source of this inflammation.
It works by attaching to certain proteins on immune cells to block some of the inflammatory signals that contribute to asthma.
So just like adding a spam filter could help Mike reduce his spam calls, adding DUPIXENT can help you reduce your asthma symptoms.
In fact, DUPIXENT was proven to help reduce asthma attacks by up to 81%, and in a study of people who needed oral steroids, 86% of people reduced or eliminated their oral steroid dose.
The most common side effects in patients with asthma include injection site reactions, high count of a certain white blood cell (eosinophilia), pain in the throat (oropharyngeal pain), and parasitic (helminth) infections.
With his newly-installed spam filter, Mike gets fewer spam calls and can do more of what he loves.
What could you do with less asthma?
If your current therapy isn't doing enough, talk to your doctor about DUPIXENT, the first-of-its-kind asthma treatment proven to help patients breathe better in as little as two weeks. Stay tuned for additional Important Safety Information.
A Look Inside: The Science of DUPIXENT
Discover how DUPIXENT works within the body to target
airway inflammation, combat asthma symptoms, and
help to improve breathing.
WHEN SHOULD YOU CONSIDER DUPIXENT?
Hear real DUPIXENT patients Rachel and Sharron share their
struggles with asthma and what led them to DUPIXENT as a
treatment option.
With DUPIXENT, I’m able to do
more of what I want to do and
with less asthma.
Sharron,
Real patient.
Individual results may vary.
Real patient.
Individual results may vary.
Transcript
SHARRON: I have lived with severe asthma most of my life. It developed early on when I was in middle school, and then as an adult, I had to use my rescue inhaler very frequently and the nebulizer as well.
RACHEL: I was diagnosed with severe asthma at the age of ten.
I had a lot of coughing, wheezing, feeling short of breath. My chest would get tight. We tried a lot of different asthma medications, but I would still end up in the hospital a couple of times a year. It had a really big impact on my life.
SHARRON: So, my doctor treated my asthma with rescue inhalers, anti-inflammatories, oral steroids and long-acting inhalers. They weren’t managing the asthma well; it was not controlled.
One day on a follow-up appointment, my doctor brought up DUPIXENT as an add-on therapy. He talked about it being a biologic, what that was, and I was ready for it.
If there was a chance that it could help control my asthma, then I was ready for it and willing to do whatever I needed to do.
RACHEL: When my doctor suggested DUPIXENT, I was open to it. We had a candid conversation. I asked a lot of questions. She explained to me what was going on in my body and that DUPIXENT could work for patients like me, so I wanted to try it.
RACHEL: Before I started DUPIXENT, I told my doctor about all the medical conditions I had and medications I was taking.
SHARRON: My doctor and I talked about the potential benefits and risks of treatment, including the most common side effects such as injection site reactions, and some serious side effects including allergic reactions that can sometimes be severe, inflammation of your blood vessels, and joint aches and pain.
RACHEL: After starting DUPIXENT, I was able to do some of my simple, everyday activities without my asthma getting in the way as often, like running around the yard with my dogs, helping with the outdoor chores.
SHARRON: Over time I noticed that the wheezing decreased. I didn’t have to use my rescue inhaler as often, and I think the best of all was that I was able to sing and hold the note.
RACHEL: I never thought that I would be where I am in my asthma journey. It’s a very good feeling. I feel a lot of relief knowing that my asthma is better controlled.
SHARRON: It feels great to be able to manage my asthma better.
RACHEL: I’ve learned to be a good advocate for myself and that I do not have to accept uncontrolled asthma.
With DUPIXENT, I’m able to do more of
what I want to do and with less asthma.
Sharron,
Real patient.
Individual results may vary.
Real patient.
Individual results may vary.
Use This Brochure To Learn More About DUPIXENT
BENEFITS WITH EVERY BREATH
Explore the results of DUPIXENT.
frequently asked questions
DUPIXENT targets a key source of airway inflammation in your lungs to help prevent asthma attacks and reduce asthma symptoms. DUPIXENT is not a steroid or inhaler.
Learn more aboutuncontrolled asthma
Do not use DUPIXENT if you are allergic to dupilumab or to any of the ingredients in DUPIXENT.
Inactive ingredients: L-arginine hydrochloride, L-histidine, polysorbate 80, sodium acetate, sucrose, and water for injection.
Before using DUPIXENT, tell your doctor about all your medical conditions, including if you:
- have a parasitic (helminth) infection
- are scheduled to receive any vaccinations. You should not receive a "live vaccine" right before and during treatment with DUPIXENT.
- are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
- Pregnancy Exposure Registry. A pregnancy registry for women who take DUPIXENT during pregnancy collects information about the health of you and your baby. To enroll or get more information, call 1-877-311-8972 or go to https://mothertobaby.org/ongoing-study/dupixent/.
- are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.
Tell your doctor about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines or use an asthma medicine. Do not change or stop other medicines, including corticosteroid medicine or other asthma medicine, without talking to your healthcare provider. This may cause other symptoms that were controlled by those medicines to come back.
DUPIXENT was studied in the VENTURE trial, where 86% of patients reduced or eliminated their oral steroid dose with DUPIXENT 300 mg + Standard of Care (SOC) vs 68% with placebo + SOC.
Do not stop taking your corticosteroid medicines unless instructed by your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine to come back.
The most common side effects include injection site reactions, high count of a certain white blood cell (eosinophilia), and pain in the throat (oropharyngeal pain).
View the possible side effects of DUPIXENT in patients with moderate-to-severe eosinophilic or oral corticosteroid dependent asthma below.
View the possible side effectsDUPIXENT is not an immunosuppressant or steroid.