HOW DUPIXENT WORKS

YOUR DOCTOR
CAN HELP

SHARRON: My severe asthma was out of control most of my life, probably about 20 years. I didn’t always know when I was gonna have an asthma attack, and that’s part of the challenging part of living with severe asthma.

I tried prescription inhalers, nebulizers, oral corticosteroids.

These treatments were just not providing the relief that I was looking for.

When my doctor suggested DUPIXENT as an add-on maintenance treatment, I wanted to know everything. I was at a point where I was ready—we both felt that I was ready.

DR. SPORTER: I see a lot of patients like Sharron who have moderate-to-severe eosinophilic asthma that’s not controlled despite inhalers, or they have oral steroid-dependent asthma.

Their immune system is in overdrive. It's hyperactive, and when they have an asthma attack, that hyperactivity is causing them to have tight airways. For these patients, I recommend DUPIXENT.

DUPIXENT works in your immune system to help dial down that overreaction, and it's not an immunosuppressant. DUPIXENT is a biologic medication that works differently by targeting the underlying source of that inflammation.

SHARRON: I didn't know how I would respond to DUPIXENT, but I was hopeful that it could help me. At that point, I had to do something to take charge of my severe asthma, so I said, "Let's do it.” I felt that my doctor really understood my asthma, and I trusted his opinion.

DR. SPORTER: The first thing I want to do is understand their questions about DUPIXENT, and I want to make sure that I answer them and give them the opportunity to get the information they need.

I assure them that I have experience treating patients with DUPIXENT, and that patients in the clinical trials saw positive results. Over time, patients on DUPIXENT may experience decreased asthma symptoms and improved lung function. Of course, everyone's experience on DUPIXENT is different.

SHARRON: My doctor was straight with me. He kept my expectations in check, and he said, "Let's try it and see how this goes."

SHARRON: Before I started DUPIXENT, I told my doctor about all the medical conditions I had and medications I was taking.

My doctor and I talked about the potential benefits and risks of treatment, including the most common side effects such as injection site reactions, and some serious side effects including allergic reactions that can sometimes be severe, inflammation of your blood vessels, and joint aches and pain.

DR. SPORTER: Every so often, I have a patient who's on the fence about DUPIXENT because it's an injectable medication.

I explain that DUPIXENT is a biologic medication. It works different from oral medications or steroids. Most biologic medications are injections. I let them know that I'll train them to self-inject.

For my patients who are 12 and older who aren't comfortable injecting with a syringe, I let them know that there's a pre-filled single-dose pen.

SHARRON: My doctor told me that DUPIXENT was going to be an injectable. Um, that it would involve a syringe. So, when he first told me that, I was a little nervous because I have a little fear of needles.

My doctor and I spent some time talking about the self-injection. He referred me to the self-injection video on DUPIXENT.com.

He also said there was a team at DUPIXENT MyWay who could provide supplemental injection training to help me become more familiar with self-injecting. I felt more at ease, and I also felt that the support was there if I needed it.

DR. SPORTER: I can tell you, as a physician, it feels great to see patients like Sharron come in and have improved symptoms on DUPIXENT. It's important to keep in mind that a patient's individual results with DUPIXENT may vary.

SHARRON: I'm so glad my doctor and I made the decision to start DUPIXENT.

VO:

Important Safety
Information and Indication

Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.

Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you:

• have a parasitic (helminth) infection
• are scheduled to receive any vaccinations. You should not receive a "live vaccine" right before and during treatment with DUPIXENT.
• are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
  • A pregnancy registry for women who take DUPIXENT during pregnancy collects information about the health of you and your baby. To enroll or get more information call 1-877-311-8972 or go to https://mothertobaby.org/ongoing-study/dupixent/.
• are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines or use an asthma medicine. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine or other asthma medicine to come back.

DUPIXENT can cause serious side effects, including:

• Allergic reactions. DUPIXENT can cause allergic reactions that can sometimes be severe. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms: breathing problems or wheezing, swelling of the face, lips, mouth, tongue, or throat, fainting, dizziness, feeling lightheaded, fast pulse, fever, hives, joint pain, general ill feeling, itching, skin rash, swollen lymph nodes, nausea or vomiting, or cramps in your stomach-area.
• Inflammation of your blood vessels. Rarely, this can happen in people with asthma who receive DUPIXENT. This may happen in people who also take a steroid medicine by mouth that is being stopped or the dose is being lowered. It is not known whether this is caused by DUPIXENT. Tell your healthcare provider right away if you have: rash, chest pain, worsening shortness of breath, a feeling of pins and needles or numbness of your arms or legs, or persistent fever.
• Joint aches and pain. Some people who use DUPIXENT have had trouble walking or moving due to their joint symptoms, and in some cases needed to be hospitalized. Tell your healthcare provider about any new or worsening joint symptoms. Your healthcare provider may stop DUPIXENT if you develop joint symptoms.

The most common side effects in patients with asthma include injection site reactions, high count of a certain white blood cell (eosinophilia), pain in the throat (oropharyngeal pain), and parasitic (helminth) infections.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Use DUPIXENT exactly as prescribed by your healthcare provider. It’s an injection given under the skin (subcutaneous injection). Your healthcare provider will decide if you or your caregiver can inject DUPIXENT. Do not try to prepare and inject DUPIXENT until you or your caregiver have been trained by your healthcare provider. In children 12 years of age and older, it’s recommended DUPIXENT be administered by or under supervision of an adult. In children 6 to less than 12 years of age, DUPIXENT should be given by a caregiver.

Please see accompanying full Prescribing Information including Patient Information.

Indication

DUPIXENT is a prescription medicine used with other asthma medicines for the maintenance treatment of moderate-to-severe eosinophilic or oral steroid dependent asthma in adults and children 6 years of age or older whose asthma is not controlled with their current asthma medicines. DUPIXENT helps prevent severe asthma attacks (exacerbations) and can improve your breathing. DUPIXENT may also help reduce the amount of oral corticosteroids you need while preventing severe asthma attacks and improving your breathing. DUPIXENT is not used to treat sudden breathing problems. It is not known if DUPIXENT is safe and effective in children with asthma under 6 years of age.