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Why DUPIXENT?

A Unique Treatment Approach

Whether you’re a patient or a caregiver of someone with EoE, we understand what you’re going through. DUPIXENT targets an underlying cause of EoE to help control symptoms.

FDA-approved

DUPIXENT is the first and only FDA-approved treatment of its kind for EoE in patients as young as 1 year old, weighing at least 33 lb.

Reduces inflammation

DUPIXENT targets a source of inflammation that can lead to EoE. It is not a steroid or immunosuppressant.

Proven results

In clinical trials, DUPIXENT reduced inflammation in the esophagus in both adults and children as young as 1 year old, weighing at least 33 lb.*

Demonstrated safety

DUPIXENT has a demonstrated safety profile in both adults and children as young as 1 year old, weighing at least 33 lb.*

*Based on clinical trials with 240 adult and pediatric patients (12+ years of age, weighing at least 88 lb) with EoE at Week 24 and results from 61 patients ages 1-11 years old (≥33 lb) with EoE.

The most common side effects in patients with eosinophilic esophagitis include: injection site reactions, upper respiratory tract infections, cold sores in your mouth or on your lips, and joint pain (arthralgia).

1 Dose Given Weekly or Every Other Week†

†Depending on patient’s weight (ages 1 year and older, weighing at least 33 lb).

A Look Inside: How DUPIXENT Works for EoE

Learn how DUPIXENT works to target an underlying inflammation that can contribute to EoE.

TRANSCRIPT

VO:
DUPIXENT is a prescription medicine used to treat adults and children 1 year of age and older with eosinophilic esophagitis (EoE), who weigh at least 33 pounds (15 kg). It is not known if DUPIXENT is safe and effective in children with eosinophilic esophagitis under 1 year of age, or who weigh less than 33 pounds (15 kg).

Important Safety Information

Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.

Please see additional Important Safety Information throughout this video and adjacent links for full Prescribing Information including Patient Information.

PIXI: Hey there! I’m Pixi, and I help people learn more about DUPIXENT® (dupilumab). Today, we’re taking an ‘inside look’ at eosinophilic esophagitis, otherwise known as EoE, and how DUPIXENT works to help reduce symptoms, such as difficulty swallowing.

This is Marc—he knows firsthand what it’s like to live with this chronic, progressive condition. In a second, we'll listen in on a few of the conversations he, his parents, and his healthcare providers have had over the years.

A LOOK INSIDE: MARC’S EOE STORY

[SCENE 1: CONVERSATION BETWEEN MARC’S PARENTS]

MARC’S MOM: We’ve tried everything the pediatrician suggested. We’ve tried to eliminate certain foods—eggs, milk, and wheat—but he’s still having trouble eating.

MARC [COUGHING/MAKING A CLEARING SOUND]: I’m not hungry anymore, Mom. But can I have some more water?

MARC’S MOM: See? He barely ate anything, and he’s been sitting there for an hour.

MARC’S DAD: Yeah, he’s such a slow eater these days. And he’s always cutting his food into really tiny pieces and drinking a lot of water. He says he’s OK, but I’m not so sure.

MARC’S MOM: Marc gets a lot of stomachaches, too. The other day, he went to the bathroom after dinner, and it sounded like he was trying to vomit. Something just isn’t right.

PIXI: Something isn’t right. Marc’s parents and his healthcare providers haven’t put their finger on it yet, but his symptoms—difficulty swallowing, abdominal pain, vomiting, and chest pain—are pretty typical for a teen living with EoE.

EoE is a relatively newly recognized condition and can be widely underdiagnosed and misdiagnosed. Did you know that EoE symptoms are often confused for food allergies or digestive conditions such as GERD, or gastroesophageal reflux disease?

But EoE is actually a chronic condition that can damage the esophagus—the tube that connects the throat to the stomach—over time. People with EoE have inflammation in the esophagus, contributing to difficulty swallowing and other symptoms.

[SCENE 2: MARC CONVERSES WITH A FRIEND AT COLLEGE]

PIXI: By the time Marc got to college, his symptoms had gotten significantly worse.

MARC’S FRIEND: So, Marc, what happened the other night? You were there one minute and gone the next.

MARC: Yeah, I felt like I had food stuck in my chest. So embarrassing. I just wanted pizza on my birthday, but I couldn’t even get the first bite down. I tried drinking a bunch of water to get it down. I even went to the bathroom and tried to bring it up, but it wouldn’t budge. My girlfriend eventually had to take me to the ER to have the doctor remove it.

MARC’S FRIEND: I am so sorry that happened to you! You’re super careful about what you eat.

MARC: I know! I’m glad I got help. But the ER’s not a fun place to spend your birthday.

MARC’S FRIEND: That sounds awful!

MARC: It was! They had to dilate my esophagus after removing the food. I've been doing what my doctor told me to do—taking a PPI, or proton pump inhibitor but it just doesn’t seem to be getting any better.

PIXI: People living with EoE have a chronically inflamed esophagus. Difficulty swallowing? That’s a common symptom. And, yes, food can literally get stuck in the esophagus before reaching the stomach.

Pills like PPI's, slurries formed from steroids, and food elimination diets may provide symptom relief. DUPIXENT targets an underlying source of inflammation. When you have EoE, overactive immune cells in your esophagus send out too many inflammatory signals. All this excessive signaling leads to more inflammation.

Some foods and environmental allergens can then cause a buildup of inflammatory cells which leads to even more inflammation, difficulty swallowing, also known as dysphagia, and eventually narrowing of the esophagus.

By the time he was 20, Marc's symptoms had only gotten worse—eating solid food had become incredibly difficult for him.

[SCENE 3: ADULT MARC TALKS WITH HIS GASTROENTEROLOGIST]

PIXI: After his visit to the ER, Marc’s gastroenterologist suspected EoE. They conducted an upper endoscopy and did a biopsy to confirm the diagnosis.

GASTROENTEROLOGIST: Marc, the biopsy of your esophagus confirms you have EoE. If left uncontrolled, your symptoms will persist.

MARC: All this time, the issue has been my esophagus? It is a relief to finally know what’s going on, but is there anything I can do about it?

GASTROENTEROLOGIST: There is no cure for EoE, but there is data that DUPIXENT improved eosinophilic inflammation and difficulty swallowing. It’s the first FDA-approved treatment of its kind for EoE.

DUPIXENT targets an underlying source of inflammation that contributes to EoE and reduces EoE symptoms. It works by attaching to certain proteins on your immune cells to block some of the inflammatory signals that contribute to EoE. Adding DUPIXENT to your treatment plan may help reduce the inflammation that contributes to EoE. And it was clinically proven to help reduce difficulty swallowing.

The most common side effects in patients with eosinophilic esophagitis include injection site reactions, upper respiratory tract infections, cold sores in your mouth or on your lips, and joint pain (arthralgia).

PIXI: Suspect you or someone you love 1 year or older may be living with EoE? Don’t wait for things to get worse. Talk to an EoE specialist, such as a gastroenterologist or allergist, about DUPIXENT, a breakthrough treatment for EoE.

Just like Marc, you or a loved one may finally get the relief you’ve been looking for.

Please stay tuned for additional Important Safety Information.

For more on life with DUPIXENT, explore
recommended dosing and administration options.

DUPIXENT Dosing for EoE  

Results in Adults AND ADOLESCENTS at 24 Weeks

Based on a clinical trial with 240 adult and pediatric patients (12+ years weighing at least 88 lb) with EoE at Week 24:

DUPIXENT was proven to

IMPROVE SWALLOWING

DUPIXENT

reduced INFLAMMATION
IN THE ESOPHAGUS

The most common side
effects include:

  • Injection site reactions
  • Upper respiratory tract infections
  • Cold sores in your mouth or on your lips
  • Joint pain (arthralgia)

View the possible side effects of DUPIXENT in patients with eosinophilic esophagitis.

Ready to Ask
Your Doctor
About DUPIXENT?

Ahead of your next visit, fill out this interactive guide to assess symptoms and how EoE
has affected you or your loved one. This could help your gastroenterologist (GI)
understand whether DUPIXENT may be an appropriate treatment option.

Personalize your guide

Results in Children

Based on a clinical trial with 61 patients (ages 1 to 11 years weighing at least 33 lb) with EoE in a 2-part study:

DUPIXENT

reduced INFLAMMATION
IN THE ESOPHAGUS

Caregivers observed that children

experienced FEWER DAYS WITH
EoE SIGNS AND SYMPTOMS

as early as 4 months and at 1 year†

VISIBLE IMPROVEMENTS
IN THE ESOPHAGUS

were seen in children

†As measured by the Pediatric Eosinophilic Esophagitis Sign/Symptom Questionnaire for Caregivers (PESQ-C).

The most common side
effects include:

  • Injection site reactions
  • Upper respiratory tract infections
  • Cold sores in your mouth or on your lips
  • Joint pain (arthralgia)

View the possible side effects of DUPIXENT in patients with eosinophilic esophagitis.

Is DUPIXENT right
for your loved one?

Fill out our personalized discussion guide to learn how to communicate your loved one's
EoE symptoms to a healthcare provider and discover whether DUPIXENT could help.

Personalize your guide

Learn More With the Patient Brochure

Learn More With the Patient Brochure

For more on how DUPIXENT treats EoE, download the
patient brochure.

Download Brochure

Discover Your EoE Community

Your EoE journey may be unique, but you’re not alone. Explore our educational webinars to hear from others with EoE and how DUPIXENT helped them find relief from their symptoms.

Find a Webinar

Looking for More Personal
Guidance?

Connect with a DUPIXENT MyWay® Mentor to speak one-on-one with others who have been in your shoes.

Connect with
a Mentor

FREQUENTLY ASKED QUESTIONS

DUPIXENT is indicated for the treatment of adult and pediatric patients aged 1 year and older who weigh at least 33 lb (15 kg) with eosinophilic esophagitis (EoE).

Fill out our personalized doctor discussion guide to help guide your conversation with your doctor and discover whether DUPIXENT may be right for you.

DUPIXENT is a biologic. Biologics are specialty medicines made inside living cells and designed to target specific parts of the immune system involved in a particular disease. They are processed in the body differently than oral or topical medications. To be effective and work properly, most biologics are delivered by injection.

DUPIXENT targets an underlying source of inflammation, which contributes to EoE.

Before using DUPIXENT, tell your doctor about all your medical conditions, including if you:

  • have a parasitic (helminth) infection.
  • are scheduled to receive any vaccinations. You should not receive a "live vaccine" right before and during treatment with DUPIXENT.
  • are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines or if you have EoE and asthma and use an asthma medicine. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine or other asthma medicine to come back.

DUPIXENT can cause serious side effects, including:

  • Allergic reactions. DUPIXENT can cause allergic reactions that can sometimes be severe. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms:
    • breathing problems or wheezing
    • swelling of the face, lips, mouth, tongue, or throat
    • fainting, dizziness, feeling lightheaded
    • fast pulse
    • fever
    • hives
    • joint pain
    • general ill feeling
    • itching
    • skin rash
    • swollen lymph nodes
    • nausea or vomiting
    • cramps in your stomach-area
  • Joint aches and pain. Some people who use DUPIXENT have had trouble walking or moving due to their joint symptoms, and in some cases needed to be hospitalized. Tell your healthcare provider about any new or worsening joint symptoms. Your healthcare provider may stop DUPIXENT if you develop joint symptoms.

The most common side effects of DUPIXENT in patients with eosinophilic esophagitis include: injection site reactions, upper respiratory tract infections, cold sores in your mouth or on your lips, and joint pain (arthralgia).

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all of the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

In May 2022, the U.S. Food and Drug Administration (FDA) approved DUPIXENT to treat patients with EoE aged 12 years and older, weighing at least 40 kg. In January 2024, the FDA expanded DUPIXENT’s approval to treat patients with EoE aged 1 year and older, weighing at least 15 kg.