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call 1-844-DUPIXENT, option [1] or
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Why DUPIXENT?
Results with DUPIXENT: The Science Behind Nasal Polyps Relief
DUPIXENT was studied in one of the largest nasal polyps biologics trial programs to date, including 724
adult patients.
Reduced nasal congestion by as much as 50%a
Can improve the ability to smell in as little as 3 daysb
Reduced the need for oral steroids
83% fewer patients required nasal polyp surgeryc
Do not change or stop your corticosteroid medicine without talking to your healthcare provider.
a For patients on DUPIXENT 300 mg in 24-week and a 52-week clinical trial vs 17% for placebo group.
b Individual results may vary.
c Compared to placebo + standard of care (SOC).
How Symptoms Can Improve Over Time
Patients on DUPIXENT can experience an improvement in the ability to smell in as little as 3 days. Patients also saw relief at Week 24 and Week 52 of treatment. Click the tabs below to view the results of the SINUS-52 trial.
Before treatment with DUPIXENT
Nasal polyps and nasal congestion
are present
DAY 3 OF TREATMENT with DUPIXENT
Some patients saw improvement in
nasal congestion and ability to smell as
early as Day 3
Analysis on Day 3 was not evaluated during the clinical trial,
and any results at Day 3 may be due to chance.
WEEK 4 OF TREATMENT with DUPIXENT
Nasal polyps begin to show
measurable shrinkage
WEEK 24 OF TREATMENT with DUPIXENT
Significant
shrinkage:
28%
improvement in nasal polyp burden
vs 2% worsening
with placebo
Less nasal
congestion:
47%
improvement in nasal
congestion
vs 16% with placebo
Based on analysis on Week 24 during SINUS-52 clinical trial of
adult patients receiving DUPIXENT (n=295) vs placebo (n=153).
WEEK 52 OF TREATMENT with DUPIXENT
Significant
shrinkage:
37%
improvement in nasal polyp burden
vs 5% worsening
with placebo
Less nasal
congestion:
56%
improvement in nasal congestion
vs 15% with placebo
Based on analysis on Week 52 during SINUS-52 clinical trial of
adult patients receiving DUPIXENT (n=150) vs placebo (n=153).
Select a time period
to see the results.
All adult patients were on background intranasal corticosteroids.
Individual Results May Vary.
Images are illustrative only.
DUPIXENT Had a Demonstrated Safety Profile in Clinical Trials
The most common side effects include:
- Injection site reactions
- High count of a certain white blood cell (eosinophilia)
- Joint pain (arthralgia)
- Eye and eyelid inflammation, including redness,
swelling, and itching - Gastritis
- Trouble sleeping (insomnia)
- Toothache
View the possible side effects of DUPIXENT in patients with uncontrolled chronic rhinosinusitis with nasal polyps.
The use of DUPIXENT in patients 12-17 years of age is supported by the efficacy and safety results from studies done in adults
with uncontrolled nasal polyps.
What other information about DUPIXENT would be helpful before talking to your doctor?
Please select one.
Commercially insured patients may pay as little as $0* copay per fill of DUPIXENT, and 98% of patients are covered. Learn more about the cost of DUPIXENT.
*Approval is not guaranteed and is subject to the program maximum per patient per calendar year.
Explore Pricing and InsuranceYou’ll need a prescription to get started with DUPIXENT. Answer some questions to prepare for a conversation with your doctor to find out if DUPIXENT may be right for you or your child.
Start Doctor Discussion GuideMany nasal polyps patients have seen improvement following treatment with DUPIXENT.
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Sign Up for EmailsUse DUPIXENT exactly as prescribed by your healthcare provider. Your healthcare provider will tell you how much DUPIXENT to inject and how often to inject it. DUPIXENT is a biweekly injection that can be administered at home by you or your caregiver after proper training by your doctor, or given by your doctor in a clinic or doctor's office. Find tutorials, instructions, and more from our injection support center.
Browse InjectionSupport Center
How DUPIXENT Works to Improve Uncontrolled Nasal Polyps
DUPIXENT is a form of medicine called a biologic that is injected every 2 weeks.
Targets type 2 inflammation
DUPIXENT targets two of the sources of a chronic inflammation that can act as an underlying cause of nasal polyps.
An alternative to surgery
While surgery can remove nasal polyps, it may not treat an underlying cause.
How DUPIXENT can help
DUPIXENT helps to treat an underlying inflammation in nasal polyps. DUPIXENT can help shrink nasal polyps and improve congestion.
Targeting Inflammation
From the Inside
Learn more about how DUPIXENT works inside the body to help treat nasal polyps.
Download the Patient Brochure to Learn More
FREQUENTLY ASKED QUESTIONS
DUPIXENT is a prescription medicine used with other medicines for the maintenance treatment of chronic rhinosinusitis with nasal polyps (CRSwNP) in adults and children 12 years of age and older whose disease is not controlled. It is not known if DUPIXENT is safe and effective in children with CRSwNP under 12 years of age. DUPIXENT is not a steroid or immunosuppressant.
Fill out your personalized doctor discussion guide andask your doctor if DUPIXENT may be right for you
Type 2 inflammation is an underlying cause of nasal polyps in up to 80% of patients. Nasal polyps are predominantly characterized by type 2 inflammation of the nose and paranasal sinuses. DUPIXENT helps block two key sources of type 2 inflammation. This can result in shrinking of nasal polyps and reducing the need for surgery.
The effectiveness and safety of DUPIXENT has been studied in the largest clinical trials to date for nasal polyps, with 724 adults with uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP).
- In both studies, DUPIXENT was proven to help patients breathe better by relieving nasal congestion and reducing the size of nasal polyps compared to placebo group.
Patients enrolled in these studies included subjects with nasal polyps regardless of whether they had prior sino-nasal surgery or treatment with, or who were ineligible to receive or were intolerant to, systemic corticosteroids in the past 2 years. Patients with chronic rhinosinusitis without nasal polyps were not included in these trials.
In clinical trials, DUPIXENT reduced nasal congestion and nasal polyp size in adult patients with uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP).
In clinical studies, a symptom measurement tool showed that adults taking DUPIXENT saw less nasal congestion in as little as 2 days. Learn more about these trials and how DUPIXENT may help treat your symptoms.
In clinical trials, DUPIXENT reduced nasal congestion and nasal polyp size in adult patients with uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP) and improved the ability to smell.
In clinical studies, a symptom measurement tool showed that adults taking DUPIXENT saw an improved ability to smell in as little as 3 days.