RESULTS WITH DUPIXENT
DUPIXENT WAS STUDIED IN ONE OF THE LARGEST CRSwNP
BIOLOGICS TRIAL PROGRAMS TO DATE
Results showed improvement in key areas for adult patients with CRSwNP
These trials included 724 adults with uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP).
Can improve the
ability to smell
in as
little as 3 daysa
Significant reduction
in nasal polyp size
Reduced nasal congestion by as
much as 50%b
83% fewer patients
required
nasal polyp
surgeryc
a Individual results may vary.
b For patients on DUPIXENT 300 mg in 24-week and a 52-week clinical trial vs 17% for placebo group.
c Compared to placebo + standard of care (SOC).
Patients on DUPIXENT can experience an improvement in the ability to smell in as little as 3 days. Patients also saw relief at Week 24 and Week 52 of treatment. Click the tabs below to view the results of the SINUS-52 trial (n=295).
Before treatment with DUPIXENT
Nasal polyps and nasal congestion
are present
DAY 3 OF TREATMENT with DUPIXENT
Some patients saw improvement in
nasal congestion and ability to smell as
early as day 3
Analysis on Day 3 was not evaluated during the clinical trial,
and any results at Day 3 may be due to chance.
WEEK 4 OF TREATMENT with DUPIXENT
Nasal polyps begin to show
measurable shrinkage
WEEK 24 OF TREATMENT with DUPIXENT
Significant
shrinkage:
28%
improvement in nasal polyp burden
vs. 2% worsening
with placebo
Less nasal
congestion:
47%
improvement in nasal
congestion
vs. 16% with placebo
Based on analysis on week 24 during SINUS-52 clinical trial of
adult patients receiving DUPIXENT (n=295) vs placebo (n=153).
WEEK 52 OF TREATMENT with DUPIXENT
Significant
shrinkage:
37%
improvement in nasal polyp burden
vs. 5% worsening
with placebo
Less nasal
congestion:
56%
improvement in nasal congestion
vs. 15% with placebo
Based on analysis on week 52 during SINUS-52 clinical trial of
adult patients receiving DUPIXENT (n=295) vs placebo (n=153).
Select a time period
to see the results.
All adult patients were on background intranasal corticosteroids.
Individual Results May Vary.
Images are illustrative only.
The most common side effects include:
- Injection site reactions
- Eye and eyelid inflammation, including
redness, swelling, and itching - High count of a certain white blood
cell (eosinophilia) - Gastritis
- Joint pain (arthralgia)
- Trouble sleeping (insomnia)
- Toothache
View the possible side effects of DUPIXENT in patients with uncontrolled chronic rhinosinusitis with nasal polyps.
The use of DUPIXENT in patients 12-17 years of age is supported by the efficacy and safety results from studies done in adults with CRSwNP.
ROAD TO RELIEF
Hear from real patients and discover the benefits and results of DUPIXENT for nasal polyps treatment.
Using DUPIXENT
KATHY:
Okay. So, the card reads, what has your experience been using DUPIXENT? Mark, why don't you kick us off?
MARK:
Thanks, Kathy. When I started using DUPIXENT, I was on the verge of getting another surgery. I really didn't want to have to do that. I didn't mind when I heard DUPIXENT was an injection under the skin, and that I would be able to receive training on how to do it at home. After training, my wife handled my first few injections until I was comfortable enough to do it myself. Self-injecting was easier than I had expected.
MARK:
Before I started DUPIXENT, I told my doctor about all the medical conditions I had and medications I was taking. My doctor and I talked about the potential benefits and risks of treatment including the most common side effects, such as injection site reactions, and some serious side effects, including allergic reactions that can sometimes be severe, eye problems, inflammation of your blood vessels, and joint aches and pain.
MARK:
After a few weeks into my DUPIXENT treatment, I could smell some things. My doctors were pleased with my progress, but I know this is just my experience, and everyone's experience with DUPIXENT is different. Martin, what was it like for you?
MARTIN:
I was hesitant to add another medication to my routine at first. But after learning that the injections were given every other week, I was more confident that DUPIXENT could be right for me. I talked with my doctor. I did my research. And together, we decided to move forward with the treatment.
After my doctor taught me how to selfinject, a Dupixent MyWay nurse educator came by, she came to my house.
After the first few injections, I noticed that when I drove to work, I didn't have to put that tissue up in my nose anymore like before.
KATHY:
Well, I'm the outlier from you two guys. I'm still not self-injecting yet. I don't live that far from my doctor's office. So, I put it on the calendar just like you do. It comes to the house every couple of weeks. I take it out in advance. And then I just drive up to my doctor's office. My nurse gives my shot, and I'm—and I'm done.
A few weeks after my first injection, I was in my kitchen making coffee, and I realized I could actually smell it. Now, I always try to appreciate being able to smell in the moment.
MARTIN:
I completely agree about enjoying the moment more. I even get reminders, you know, from DUPIXENT that I can add to my calendar reminding me of my injections.
MARK:
I like to set a reminder on my phone for dosing days. That way, I always know when to take DUPIXENT. I come home, take it out of the fridge, put it on the counter. We have dinner and then five minutes—it takes me five minutes to do the injection after dinner. So, for me, even though it seemed like it was going to be easy, it was a little bit challenging, but the training really helped. My family helped me out. And then I was finally able to do it myself, and now everything goes well.
And I'm with Martin. I really take in the moments with my family and friends with so much more gratitude.
HAVE A PRODUCTIVE CONVERSATION
WITH YOUR DOCTOR
Personalize your doctor discussion guide
Our goal is for you or your loved one to get the most out of your visit to the doctor. Use our doctor discussion guide to help personalize your next visit.
Less Nasal Polyps. More You.
With DUPIXENT, you can do more of what matters most
In clinical studies, utilizing a symptom measurement tool, people taking DUPIXENT saw a meaningful improvement in their nasal polyps symptoms, which included, but were not limited to:
- Nasal blockage
- Facial pain/pressure
- Difficulty falling asleep
- Fatigue
- Decreased sense of smell/taste
The relationship between DUPIXENT and its effect on individual symptoms was studied by a multi-symptom questionnaire, but not definitively proven. Ask your doctor how DUPIXENT may help.
Find a specialist who treats Nasal Polyps
Sometimes your doctor may need to partner with a specialist in diagnosing and treating your CRSwNP. Your nasal polyps specialists have access to tools your provider may not have.
The DUPIXENT MyWay® Copay Card may help eligible patients cover the out-of-pocket cost of DUPIXENT. Terms & Restrictions Apply.
FREQUENTLY ASKED QUESTIONS
The effectiveness and safety of DUPIXENT has been studied in the largest clinical trials to date for CRSwNP with 724 adults with uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP).
- In both studies, DUPIXENT was proven to help patients breathe better by relieving nasal congestion and reducing the size of nasal polyps compared to placebo group.
Patients enrolled in these studies included subjects with CRSwNP regardless of whether they had prior sino-nasal surgery or treatment with, or who were ineligible to receive or were intolerant to, systemic corticosteroids in the past 2 years. Patients with chronic rhinosinusitis without nasal polyps were not included in these trials.
In clinical trials, DUPIXENT reduced nasal congestion and nasal polyp size in adult patients with uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP).
In clinical studies, utilizing a symptom measurement tool, adults taking DUPIXENT saw less nasal congestion in as little as 2 days. Learn more about these trials and how DUPIXENT may help treat your symptoms.
In clinical trials, DUPIXENT reduced nasal congestion and nasal polyp size in adult patients with uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP) and improved the ability to smell.
In clinical studies, utilizing a symptom measurement tool, adults taking DUPIXENT saw an improved ability to smell in as little as 3 days.